Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Autoanticorpos/sangue , Doenças Autoimunes/imunologia , Ataxia Cerebelar/imunologia , Glutamato Descarboxilase/imunologia , Imunoglobulinas Intravenosas/uso terapêutico , Doenças Autoimunes/terapia , Ataxia Cerebelar/terapia , Imunoglobulinas Intravenosas/imunologia , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
The immunogenicity and the protective efficacy of a recombinant DNA hepatitis B vaccine, GenHevac B Pasteur with or without passive immunization with hepatitis B immunoglobulin (HBIG) in high risk neonates born from HBsAg and HBeAg positive mothers was evaluated. Twenty-six neonates (group A) received HBIG 100 IU intramuscularly at birth plus GenHevac B Pasteur 20 micrograms at birth, 1, 2 and 12 months of age while another 23 neonates (group B) received only GenHevac B Pasteur vaccine. Forty high risk newborns who received no immunization served as control group. It was found that at months 4, 12, 13 and 24 the seroconversion rate in both group A and B were very high in the range of 95-100% with the GMT ranging from 10-160,000 mlU/ml. In the control group of infants, 85% had HBsAg positive at one year of age but it was only 3.8% and 8.7% in vaccinated groups A and B, respectively. The protective efficacy in neonates group A and B were 95.5% and 89.8% at one year, respectively, with no statistically significant difference. In 46 normal school children (group C) and 48 healthy adults (group D) who received the same dose of GenHevac B Pasteur the seroconversion rates at month 4 after receiving 3 doses of vaccination were 97.8% and 83.3% in group C and group D, respectively. At month 12, the seroconversion rate in group C rose to 100% and was significantly higher than the 89.6% of group D.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Hepatite B/imunologia , Anticorpos Anti-Hepatite B/biossíntese , Vacinas contra Hepatite B/administração & dosagem , Humanos , Imunoglobulinas Intravenosas/imunologia , Lactente , Recém-Nascido , Injeções Intramusculares , Masculino , Fatores de Risco , Vacinas Sintéticas/administração & dosagemRESUMO
An in vitro study of the effect of immunoglobulins (mainly IgG) on opsonophagocytic activity of polymorphs was carried out in 17 tracheostomised patients admitted in medical intensive care unit of our hospital. The opsonic and phagocytic activities were tested against Staphylococcus aureus by modified polymorphonuclear leucocyte overlay method; and serum IgG and serum IgM levels were estimated by single radial immunodiffusion technique. As compared to healthy volunteers, opsonophagocytic activity was significantly lower in tracheostomised patients. However, this activity improved markedly after immunoglobulin supplementation (P less than 0.01). The same degree of enhancement was also observed in normal controls.